comparative study of the topical tacrolimus versus topical calcipotriol in / ptients with hand and facial vitiligo

Background and Objectives: Vitiligo is an acquired disease due to progressive lack of performance of melanocytes and appears as ring depigmentated patches and macules. About%2 of people are involved and because of unpleasant appearance, it creates emotional stress on patients .So new and better treatments are needed. This study was conducted to compare effectiveness of topical tacrolimus with topical calcipotriol in pigmentation of vitiligo patients

Materials and Methods:This study was done in double-blind randomized clinical trial on patients facial and hand vitiligo with under%20 involvement of body surface. Patients were categorized in two groups with tacrolimus and calcipotriol treatments and were evaluated and followed up for 12 months

Results: In statistical analysis, there was no significant difference between the effects of both dings on progression of pigmentation, but their on facial vitiligo was better than hand vitiligo [p=0.04].Side effects of treatment in both groups were mild and no serious side effects were reported, but Tacrolimus had significantly minimal side effects rather than Calcipotriol [p=0.02]

Conclusions: In this study,efficacy of topical tacrolimus was better than topical calcipotriol on face and efficacy of calcipotriol was better than tacrolimus on hand vitiligo

Comparison of blood glucose level in diabetics undergoing orthopedic surgeries with general or spinal anesthesia

Background: Diabetes increases the risk of peri-operative morbidity and mortality and research to decrease intraoperative blood glucose variations has been continued without any results. The objective of this study was to evaluate the blood glucose level in diabetics undergoing orthopedic surgeries with general or spinal anesthesia

Methods: In this prospective cross-sectional descriptive analytic study the blood glucose levels were evaluated in 80 diabetic patients undergoing orthopedic surgeries during general and spinal anesthesia before surgery, after incision, after one hour and in recovery

Results: 25 patients were male and 55 were female. The age of patients in spinal group was 64.90+/- 10.73 and in general group 60.78+/-10.86 years old. Body Mass Index in spinal group was 27.85+/-3.69 and in general group 29.43+/-3.57. Blood glucose levels were not significantly different between two groups. The blood glucose levels were significant in samples taken between incision and recovery period in both groups

Conclusions: The blood glucose level during surgery and anesthesia has been increased continuously and this increase in general group had a steeper slope but it was acceptable

Fetal and neonatal outcomes of the magnesium sulfate and nefidipine in suppression of preterm labor

Preterm Labor occurs in 11.8% of all pregnancies and is the most etiology of Neonatal morbidity without Anomalies and after intra-partum congenital Anomalies is the second etiology of Neonatal mortality that has high economic and psychiatric cost. Premature infants have Neurotic complications and they are week about physical growth, practical cognitive and lesson tasks. One of usage drugs in prevention of preterm labor is Nefidipin. This research is a Double blind RCT. All of pregnant mothers with 26-34 weeks with signs of preterm labor have come to Alzahra and Talegani hospitals were research population. Research samples were 80 pregnant women that have eligibility criteria and treated with Sulphate mg and Nefidipin. Samples allocated randomly in 2 groups by use of rand list software and block of 3 and 6. In group A were used Sulphate mg 4 g first and then 2g/h for 48 h and group B were used Nefidipin 20 mg first and 20 mg /half h after. Success of treatment was measured by Partograph and checklist. Data was analyzed by statistic tests and spss ver. 13. Neonatal complications such as 1 min Apgar and 5 min Apgar score, Sao2 and ABG in 2 groups, that treatment could not prevent contractions, have not significantly different. But there were significant different about Fetal complications such as bit to bit variation, decrease of fetal movement and dropt of base line of FHR [p